Thanks for pointing out dar, out definitely has some very interesting capabilities. My backup took off choice is BorgBackup as it makes local/remote, encrypted, deduplicated backups easy and allows for mounting previous snapshots via fuse fs for easy restore.
Instead of a fire safe which will only offer some protection I would rather get two Pelican style cases. Keep your backup drive(s) in there. Use a deduplicating/encrypted backup software to create two backup sets (I highly recommend BorgBackup). Store one of the backup cases off-site (at a friend’s house, in a drawer at work, …) and occasionally rotate the two cases.
Check out Clonezilla, which is the perfect tool for the job.